used in drug material Methyl Beta cyclodextrin

Methylated-β-cyclodextrin (Me-β-CD) is one of cyclodextrin derivatives that were widely used in modern researches and applications.

Me-β-CD can be soluble both in water and in organic solvents. In pharmaceuticals industry, it can increase solubility and bioavailability of drugs, so that the efficacy of drugs can last longer with less ingestion. It can adjust and control the drug release rate, reduce drug side-effects, and enhance the stability of drugs particularly for oil-soluble molecules.

In commodity chemicals and cosmetics, Me-β-CD can reduce microbial contamination and skin irritations, keep skin moist, mask bad odors, promote transdermal absorption of activeingredients.

Me-β-CD has a larger surface tension in common cyclodextrin derivatives.

Name: methyl-beta-cyclodextrin

Other name : methyl-β-cyclodextrin

CAS: 128446-36-6

Abbreviation: MEBCD

Molecular formula : C42H70-nO35 · (CH3)n

Molecular weight: 1135 + n•(14.0)

Solubility(in 100cm3 solvent, at 25℃) : water: >50g

Methanol: >50g

Chloroform: ~ 2 g

Standard : enterprise standard

Package: 500g/bag , 1kg/bag, 10kg/drum or customized

Use : medical \ chemical \ other industries

Description

Appearance	white powder, insipid, innocent	Qualify
Assay	≥98%	99.6%
Degree of Substitution	11.2-13.3	13.0
Molar of substitution	1.6-1.9	1.8
Loss on Drying	≤5.0%	3.9%
Optical density of a 10%solution (220-350nm)	≤1.0	Qualify
Optical density of a 10%solution (350-600nm)	≤0.1	Qualify
Chloride	≤0.2%	≤0.05%
Unsubstituted cyclodextrin	≤0.3%	Absent
Residue on Ignition	≤0.5%	0.39%
Heavy Metal (as pd)	≤0.0001%	＜0.0001%
Arsenic salt (AS)	≤0.0005%	＜0.0005%
Specific rotation	154-165º	156.2º
Solubility in water(25℃)	>750g/L	Qualify
TAMC(cfu/g)	≤1000	10
TYMC(cfu/g)	≤100	10
Salmonella/E. Coli (cfu/g)	Absent	Absent

Storage: at room temperature, in tightly closed container.

Characteristics and applications:

Methylated-β-cyclodextrin (Me-β-CD) is one of cyclodextrin derivatives that were widely used in modern researches and applications.

Me-β-CD can be soluble both in water and in organic solvents. In pharmaceuticals industry, it can increase solubility and bioavailability of drugs, so that the efficacy of drugs can last longer with less ingestion. It can adjust and control the drug release rate, reduce drug side-effects, and enhance the stability of drugs particularly for oil-soluble molecules.

In commodity chemicals and cosmetics, Me-β-CD can reduce microbial contamination and skin irritations, keep skin moist, mask bad odors, promote transdermal absorption of activeingredients.

Me-β-CD has a larger surface tension in common cyclodextrin derivatives.

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