Alpha-Cyclodextrin (synonyms: cyclohexaamylose, cyclomaltohexaose, alpha-Schar-dinger dextrin) is a non-reducing cyclic saccharide comprised of six glucose units linked by alpha-1, 4 bonds.
It is produced by the action of cyclodextrin glucosyltransferase (CGTase, EC 220.127.116.11) on hydrolysed starch syrups at neutral pH (6.0–7.0) and moderate temperature (35–40°C).
The annular (or doughnut-shaped) structure of alpha-cyclodextrin provides a hydrophobic cavity that allows formation of inclusion complexes with a variety of non-polar organic molecules of appropriate size.
The cavity of alpha-cyclodextrin is less than beta-cyclodextrin, so it is used to allow formation of inclusion complexes with little molecules, and the situation that needs high solubility of cyclodextrin.
The hydrophilic nature of the outer surface of the cyclic structure makes alpha-cyclodextrin water-soluble.
Other name: Cyclohexapentylose
CAS Registry Number: 10016-20-3
EINECS NO.: 233-007-4
Appearance: white crystalline or powder
Alpha cyclodextrin is widely used in the drugs, food,flavor and cosmetics. Alpha cyclodextrin is also widely used in the field of pesticide and adjusting the metabolization of the crop and increasing the quantity of the crop. Especially the cyclodextrin and its ramification which developed by these years,some of cyclodextrins are the important solutizer,stablizer, releaser or the assist materials of the Entericcoated drugs, some of cyclodextrins are the materials of organic synthetical macromolecular stuff.
a.Increase the stability of the material:Prevent volatilization, prevent sublimation; Anti-oxidation; Prevent optothermal decomposition; Anti chemical decomposition; Extend the period of validity of the material.
b.Increase the material solubility and bioavailability.
c.Through the formation of inclusion complex to achieve effective cover excitant odour.
d.Liquid drug into solid state.
e.To prevent drug - drug, drug - interaction between additive.
f.Reduce side effects