Natural Beta Cyclodextrin ,β-cyclodextrin
Beta cyclodextrin (β-CD) and Beta-cyclodextrin derivatives (β-CD) are new type drug inclusion compound developed in recent years. Hydrophilic methylation of β-CD and Hydroxypropyl cyclodextrin form inclusion compound with poorly soluble drugs, it can improve the solubility, dissolution rate and bioavailability of drugs. After Hydrophobic ethyl β-CD forms inclusion compound with water soluble drugs, it can control drug release rate. There are many kinds of cyclodextrins, but it is still the most widely used beta-CD, because β-CD has the advantages: The cavity diameter is moderate, strong combining ability, raw materials can be produced in large quantities, economical and efficiently.
Beta-Cyclodextrin (β-CD) is a kind of cyclic oligosaccharides, cyclodextrin glucanotransferase affects starch and produce 7 dextrose, the dextrose is connected throughα-1.4 glycosidic bond and forms Beta-Cyclodextrin.
Beta cyclodextrin molecules have a unique intramolecular cavity, the compound molecule is wrapped by a cyclodextrin cavity, which greatly reduces its contact with surrounding environment, and can play a lot of special effects. Beta cyclodextrin is widely applied in industry.
Beta-Cyclodextrin is used in pharmaceutical industry:
Beta-Cyclodextrin can effectively increase the solubility and dissolution rate of some water soluble drugs in water, for example, prostaglandins-CD complexes can Increase the solubility of primary drug to make injection. It can also improve the stability and bioavailability of drugs, reduce bad smell or bitter taste of drugs, lower the stimulation and toxic and side effects of drugs, also it can make drug release and improve dosage form.
Beta-Cyclodextrin is used in analytical chemistry :
Beta-Cyclodextrin is chiral compound, it has the ability to identify and choose organic molecules, which is successfully applied in various kinds of chromatography and electrophoresis methods, to separate various isomers and enantiomers. Beta Cyclodextrin can improve the selectivity of system in electrochemical analysis.
Beta-Cyclodextrin is used in cosmetics :
Beta-Cyclodextrin is used together with surfactant in shampoo and kitchen cleaning agent, it can reduce the stimulation of surfactant for skin. Beta-Cyclodextrin also can remove oil stains on the fabric. In the dyeing process, Beta-Cyclodextrin can significantly reduce initial dyeing speeds of dyestuff, to improve leveling and fiber coloring.
Beta-Cyclodextrin is used in environmental protection :
Beta-Cyclodextrin can be used in environmental protection , it can form stable inclusion complex with pollutants to reduce environmental pollution. Its unique molecular structure can be used in the treatment of industrial wastewater by biological process. In addition, Beta-Cyclodextrin can be added into air freshener, to achieve the effect of releasing slowly gas molecules and prolonging the duration of flavor.
Beta-Cyclodextrin is used in agriculture :
Pyrethroid is a kind of very important pesticide, it can solve the problem of insoluble in water and consuming a lot of organic solvent to add Beta-Cyclodextrin. This is an effective way to solve environment pollution of pyrethroid. For fish feed containing unsaturated fatty acid, wrap fatty acid with Beta-Cyclodextrin, it can prevent its diffusion into water.
Beta-Cyclodextrin is used in food industry :