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Shandong Binzhou Zhiyuan Biotechnology Co., LTD

Home > News > Application of beta cyclodextrin inclusion compound in pharmacy

Application of beta cyclodextrin inclusion compound in pharmacy

Inclusion is a kind of molecular space structure of all or part of the package into another molecule, also known as molecular capsules.Cyclodextrin is the general name of a series of cyclic oligosaccharides produced by amylose under the action of cyclodextrin glucosyltransferase produced by bacillus cereus. It usually contains 612 d-pyranoglucose units.Due to the hydrophilic outer edge of cyclodextrin and the hydrophobic inner cavity and the excellent non-toxic properties, it can bond with a variety of objects, and the inclusion compound prepared by appropriate methods can greatly improve some properties of the object.Therefore, beta cyclodextrin inclusions are widely used in many fields.For example, the application in pharmacy is as follows:1. Enhance drug stabilityDrugs that are easily oxidized and hydrolyzed are protected from light, oxygen, heat and other factors by the inclusion of cyclodextrin, thus extending the efficacy and shelf life of drugs.2. Increase the solubility and dissolution rate of drugsCyclodextrin inclusions act as molecular capsules in which drug molecules are separated and dispersed into oligosaccharide skeletons.The solubility and dissolution rate of the drug increase due to the hydroxyl interaction between the drug molecule and cyclodextrin and the decrease of the crystallinity of the drug in the inclusion.3. Cover up the bad smell and reduce irritation of drugsThe inclusion compound made of drugs with bad odor and irritation can improve the compliance of patients with medication.4. Improve bioavailability5. Improve the dosage form to improve the stability during the preparation process or at the injection site.6. Reduce pulverization or volatility of liquid drugsVolatile drugs make cyclodextrin inclusion compounds, in addition to reducing volatile, but also slow release.In the future, the industrial application of cyclodextrin will bring more development to pharmaceutical industry.1
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