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  • Shandong Binzhou Zhiyuan Biotechnology Co., LTD

  •  [Shandong,China]
  • Business Type:Manufacturer
  • Main Mark: Africa , Americas , Asia , Caribbean , Europe , North Europe , Oceania , West Europe , Worldwide , East Europe , Middle East
  • Exporter:51% - 60%
  • Certs:ISO9001, ISO14001, FDA
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Shandong Binzhou Zhiyuan Biotechnology Co., LTD

Home > News > Application of cyclodextrin inclusion compounds in pharmaceutical preparations

Application of cyclodextrin inclusion compounds in pharmaceutical preparations

Enhance the stability of drugs, easy oxidation, hydrolysis of drugs by the inclusion of cyclodextrin, from light, oxygen, heat and some factors to be protected, so as to extend the efficacy and shelf life of drugs.An inclusion compound of?? -cyclodextrin and vitamin D2 was formed.The content of VD2 in the inclusion compound was determined under the conditions of light, high temperature and high humidity.After two years, VD2 in the inclusion compound remained above 85%, while VD2 in the uninclusion compound was less than 22%. The inclusion compound of cyclodextrin solved the problem of stable content of VD2.Increasing the solubility and dissolution rate of the drug, the Cyclodextrin Inclusion Compound is equivalent to a molecular capsule, and the drug molecules are separated and dispersed in the oligosaccharide skeleton.The solubility and dissolution rate of the drug increase due to the hydroxyl interaction between the drug molecule and the cyclodextrin and the decrease of the crystallinity of the drug in the inclusion compound.It can cover up the bad smell and reduce the irritation of drugs, improve the bioavailability, improve the dosage form, and improve the stability of drugs in the process of preparation.The inclusion compound of cyclodextrin made from volatile drugs can reduce volatilization and have slow release effect.Ciprofloxacin is a kind of fluoroquinolone drug, which is commonly used in veterinary clinic in recent years.However, due to the short half-life, strong irritation, need to repeat injection, affecting its wide use.The inclusion of ciprofloxacin with -cyclodextrin delayed drug release for 72h.Cyclodextrin and its derivatives are widely used in medical field, shandong binzhou wisdom source is specializing in the production of cyclodextrins and derivatives of the company, the main products are sulfonated butyl, hydroxypropyl cyclodextrin, gamma cyclodextrins and so on more than 40 varieties, products are exported to the United States, Europe, southeast Asia and other dozens of countries and regions, by the customer consistent high praise, welcome to my company win-win cooperation, seek common development.Our r&d team will provide you with professional support and composite preparation solutions.1860 5397 11 168 Graphical Abstract
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