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Shandong Binzhou Zhiyuan Biotechnology Co., LTD

Home > News > Application Of Hydroxypropyl Beta-cyclodextrin In The Anticancer Drug Scorpion
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Application Of Hydroxypropyl Beta-cyclodextrin In The Anticancer Drug Scorpion

Horse scorpion is an anti-cancer active ingredient extracted from the horse scorpion of the family Iridium, mainly scorpion A. Clinical trials have shown that the combination of horseradish and radiotherapy can increase the CR of the tumor by more than 20%, and the survival rate of 1-5 years is significantly improved. The scorpion A is a scorpion structure with multiple unsaturated double bonds on its mother nucleus and side chain. It is chemically unstable and unstable to light. The aqueous solution is susceptible to acid-base degradation. At the same time, horse scorpion is highly hydrophobic and hardly dissolves in water and gastrointestinal fluids, directly affecting bioavailability and efficacy.

Recent studies have found that hydroxypropyl beta-cyclodextrin, which is low in toxicity and high in water solubility, can be used as an inclusion material to prepare sputum hydroxypropyl beta-cyclodextrin inclusion complex, which greatly improves its water solubility and chemistry. Stability improves the bioavailability of oral formulations.2-1Z32520013BH

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