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- Business Type:Manufacturer
- Main Mark: Africa , Americas , Asia , Caribbean , Europe , North Europe , Oceania , West Europe , Worldwide , East Europe , Middle East
- Exporter:51% - 60%
- Certs:ISO9001, ISO14001, FDA
Breviscapine was better encapsulated with hydroxypropyl betacyclodextrin
Breviscapine has the effect of dilate cerebrovascular, can reduce cerebrovascular resistance, increase cerebral blood flow, improve microcirculation, and fight platelet aggregation.It can be used for the treatment of ischemic cerebrovascular diseases, such as cerebral thrombosis, cerebral embolism, cerebral hemorrhage and other sequelae caused by paralysis patients, with good efficacy.Breviscapine is a weak acid drug insoluble in water and oil. Its solubility in organic solvents is also very small. It dissolves in acidic solutions with low oil/water distribution coefficient.Studies have shown that breviscapine is absorbed rapidly in vivo after intravenous injection, with short half-life, rapid elimination and short effective concentration.Oral tablets have low bioavailability and almost no absorption, requiring multiple doses of large doses to achieve the therapeutic purpose.Hydroxypropyl betacyclodextrin is hydrophobic inside the cylindrical structure, so the hydrophobic guest molecules are easy to be incorporated to form inclusion compounds.The study showed that the new dosage form of breviscapine was prepared by using hydroxypropyl betacyclodextrin to encapsulate breviscapine, which could effectively overcome the double disadvantages of breviscapine injection, short half-life, rapid elimination in vivo, and low bioavailability of oral administration, and at the same time ensure the curative effect of breviscapine and make the patients' medication convenient.Shandong binzhou zhiyuan biotechnology co., ltd. is a high-tech enterprise specializing in the production of hydroxypropyl betacyclodextrin, and its products are well received by customers at home and abroad.We are committed to producing better cyclodextrin products.
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Mr. Klaus chen
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