Pharmaceutical application of a novel excipient sulfobutyl ether - beta cyclodextrin
1 the sulfonated butyl ether - beta - cyclodextrin applied to injectable drugs, main is to improve the solubility of difficult soluble drugs, can make the drug injections in the rapid transfer and reach the required dosage, reduce to the parts of the injected irritating, improve the stability of the drug solution condition, moderate melting blood drug, to improve the safety of medication.2. Apply sulfobutylether-beta cyclodextrin to oral drugs, increase the bioactivity of drugs by improving the solubility of drugs, increase the stability of drugs or prolong the release time of drugs in intestines and stomach by modifying the release sites of drugs, reduce the irritation of drugs to local tissues, and cover up the unpleasant smell of some drugs.3. Application of sulfobutylether-beta cyclodextrin to nasal drug delivery, the main mechanism of improving drug delivery is to increase the permeability of nasal mucosa, improve the solubility and stability of the drug, and improve the metabolic rate of the drug at the target site of drug delivery.4. Application of sulfobutylether-beta cyclodextrin to ophthalmic drugs mainly increases the solubility and stability of drugs with poor water solubility and reduces the irritation to the cornea.