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  • Shandong Binzhou Zhiyuan Biotechnology Co., LTD

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Shandong Binzhou Zhiyuan Biotechnology Co., LTD

Home > News > The application of cyclodextrin in increasing the physical stability of drugs
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The application of cyclodextrin in increasing the physical stability of drugs

At present, cyclodextrin is most widely used to increase the physical stability of drugs, which is to reduce the dissipation of volatile drugs in the process of preparation production and storage.If betacyclodextrin was used to encapsulate cinnamon oil, zedoary turmeric oil, the surface volatility of betacyclodextrin was significantly reduced.Menthol was encapsulated with hydroxypropyl betacyclodextrin to prevent its volatilization and sublimation.The inclusion compound of borneol betacyclodextrin has been tried to improve the quality of compound danshen tablets and hemorrhoid ointment. Studies have found that the inclusion compound can not only prevent the volatilization of borneol, increase the stability, but also improve the solubility of the preparation, utilize the absorption of the drug and exert the curative effect, and the preparation process has been operated.In addition, the inclusion of cyclodextrin in pharmaceutical preparations with polymorphism may prevent the conversion of drug crystal and ensure the efficacy of drugs.1. Borneol betacyclodextrin inclusion compound: borneol has the effect of awakening the mind, clearing heat and relieving pain, but it is extremely unstable during the preparation process and storage period due to its easy sublimation. When betacyclodextrin inclusion compound is used, its light resistance, thermal stability and moisture stability are significantly increased and volatilization can be prevented.2, artificial musk times he entrapped Cyclodextrin Complex: artificial musk, because its contain a large number of volatile components, resulting in the loss, easily in the process of preparation and storage of affected containing artificial musk dosage form development and the stability of curative effect, so the artificial musk and times he made Cyclodextrin Inclusion Compound to improve the stability, for the development of artificial musk preparations, dosage form improvement and ensure the stability of the clinical efficacy of laid a certain foundation.Shandong binzhou wisdom source biological technology co., LTD. Is a specialized study of cyclodextrin and its derivatives application, development and innovation of science and technology company, the company strong technical force, with shandong university, Chinese academy of sciences and other domestic and international first-class universities and research institutes have close relations of cooperation, we would like to colleges and universities, research institutions and pharmaceutical, food, cosmetics, pesticide, the researchers in the field of new materials to provide the latest cyclodextrin derivatives.387BD887F76C1005DA115706A9209598
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